Abstract
Optically active phenylpropanoic acid derivatives [(S)-5, and (R)-5] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma were evaluated. Binding assay and cell-based reporter assay indicated that the activity of these compounds is enantio-dependent, and resides exclusively on the (S)-isomer.
MeSH terms
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Crystallography, X-Ray
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Humans
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Molecular Conformation
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Phenylpropionates / chemical synthesis*
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Phenylpropionates / pharmacology*
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Protein Binding
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Receptors, Cytoplasmic and Nuclear / agonists*
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Stereoisomerism
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Structure-Activity Relationship
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Transcription Factors / agonists*
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Transcriptional Activation
Substances
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Phenylpropionates
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors